Vitamin C: Promises Not Kept

  title={Vitamin C: Promises Not Kept},
  author={Norman B. Duerbeck and David D Dowling and Jillinda M Duerbeck},
  journal={Obstetrical \& Gynecological Survey},
&NA; Vitamin C has been suggested as beneficial in preventing and curing the common cold, decreasing the incidence of preterm delivery and preeclampsia, decreasing risk of cancer and cardiovascular disease, and improving the quality of life by inhibiting blindness and dementia. In this article, we review the hypothesized mechanisms of these purported health benefits and the evidence behind such claims. Target Audience Obstetricians and gynecologists, family physicians. Learning Objectives After… 

The Long History of Vitamin C: From Prevention of the Common Cold to Potential Aid in the Treatment of COVID-19

The most relevant studies from the prevention and treatment of common respiratory diseases to the use of vitamin C in critical illness conditions are summarized, with the aim of clarifying its potential application during an acute SARS-CoV2 infection.

Poor Vitamin C Status Late in Pregnancy Is Associated with Increased Risk of Complications in Type 1 Diabetic Women: A Cross-Sectional Study

The results may suggest that hypovitaminosis C in diabetic women is associated with increased risk of complications of pregnancy.

Assessment of Micronutrient Status in Critically Ill Children: Challenges and Opportunities

Assessment of micronutrient status in critically ill children is challenging due to many complicating factors, such as evolving metabolic demands, immature organ function, and varying methods of feeding that affect nutritional dietary intake.

Placental adaptations to micronutrient dysregulation in the programming of chronic disease

This review will explore the effects of individual vitamins, minerals and trace elements on offspring disease outcomes and discuss several key placental adaptations that are affected by multiple micronutrients.

Ascorbic acid attenuates cell stress by activating the fibroblast growth factor 21/fibroblast growth factor receptor 2/adiponectin pathway in HepG2 cells.

It is demonstrated that AA may attenuate hepatocyte stress induced by TNFα via activation of the FGF21/FGFR2/adiponectin pathway, which could a novel mechanism of action of AA, and its potential for the treatment of NAFLD/NASH.

Targeting therapeutics to endothelium: are we there yet?

Preclinical results summarized here suggest that there is hope for successful implementation of endothelial targeting agents in the years to come, as unexpected toxicities may arise with complex delivery systems.


One form of prescription service is preparing pulveres dosage form. Pulveres are generally obtained from the grinding technique of several tablet preparations and mixing them. The common grinding

Production and comparative evaluation of leather products from pawpaw (Carica papaya) and banana (Musa acuminata) fruit pulp

This research has demonstrated that processing of fruits into fruit leathers will not only minimize postharvest losses but will also create a new variety of value-added products with higher nutritional value potential compared to its fresh fruits.



Vitamins C and E to prevent complications of pregnancy-associated hypertension.

Vitamin C and E supplementation initiated in the 9th to 16th week of pregnancy in an unselected cohort of low-risk, nulliparous women did not reduce the rate of adverse maternal or perinatal outcomes related to pregnancy-associated hypertension.

Vitamin E and C in preeclampsia.

  • S. Kharb
  • Medicine, Biology
    European journal of obstetrics, gynecology, and reproductive biology
  • 2000

Vitamins C and E and the risks of preeclampsia and perinatal complications.

Benefits of supplementation with vitamins C and E during pregnancy do not reduce the risk of preeclampsia in nulliparous women, therisk of intrauterine growth restriction, or the Risk of death or other serious outcomes in their infants.

Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans.

  • A. CarrB. Frei
  • Medicine
    The American journal of clinical nutrition
  • 1999
The totality of the reviewed data suggests that an intake of 90-100 mg vitamin C/d is required for optimum reduction of chronic disease risk in nonsmoking men and women, suggesting a new RDA of 120 mg vitaminC/d.

Does supplemental vitamin C increase cardiovascular disease risk in women with diabetes?

A high vitamin C intake from supplements is associated with an increased risk of cardiovascular disease mortality in postmenopausal women with diabetes.

Vitamin C and the Risk of Preeclampsia— Results from Dietary Questionnaire and Plasma Assay

The results would suggest that current public health efforts to increase intake of fruits and vegetables rich in vitamin C and other antioxidants may reduce the risk of preeclampsia.

A critical review of vitamin C for the prevention of age-related cognitive decline and Alzheimer's disease.

  • F. Harrison
  • Biology
    Journal of Alzheimer's disease : JAD
  • 2012
Overall, there is a large body of evidence that maintaining healthy vitamin C levels can have a protective function against age-related cognitive decline and Alzheimer's disease, but avoiding vitamin C deficiency is likely to be more beneficial than taking supplements on top of a normal, healthy diet.

Examining the evidence for the use of vitamin C in the prophylaxis and treatment of the common cold

Vitamin C is frequently used for the treatment and prophylaxis of the common cold; however, no published recommendations were found in a review of the nurse practitioner literature that specifically address the efficacy of vitamin C for the commoncold.