Vitamin C: Promises Not Kept

@article{Duerbeck2016VitaminCP,
  title={Vitamin C: Promises Not Kept},
  author={N. Duerbeck and D. Dowling and Jillinda M Duerbeck},
  journal={Obstetrical \& Gynecological Survey},
  year={2016},
  volume={71},
  pages={187–193}
}
&NA; Vitamin C has been suggested as beneficial in preventing and curing the common cold, decreasing the incidence of preterm delivery and preeclampsia, decreasing risk of cancer and cardiovascular disease, and improving the quality of life by inhibiting blindness and dementia. In this article, we review the hypothesized mechanisms of these purported health benefits and the evidence behind such claims. Target Audience Obstetricians and gynecologists, family physicians. Learning Objectives After… Expand
The Long History of Vitamin C: From Prevention of the Common Cold to Potential Aid in the Treatment of COVID-19
TLDR
The most relevant studies from the prevention and treatment of common respiratory diseases to the use of vitamin C in critical illness conditions are summarized, with the aim of clarifying its potential application during an acute SARS-CoV2 infection. Expand
Poor Vitamin C Status Late in Pregnancy Is Associated with Increased Risk of Complications in Type 1 Diabetic Women: A Cross-Sectional Study
TLDR
The results may suggest that hypovitaminosis C in diabetic women is associated with increased risk of complications of pregnancy. Expand
Assessment of Micronutrient Status in Critically Ill Children: Challenges and Opportunities
TLDR
Assessment of micronutrient status in critically ill children is challenging due to many complicating factors, such as evolving metabolic demands, immature organ function, and varying methods of feeding that affect nutritional dietary intake. Expand
Placental adaptations to micronutrient dysregulation in the programming of chronic disease
TLDR
This review will explore the effects of individual vitamins, minerals and trace elements on offspring disease outcomes and discuss several key placental adaptations that are affected by multiple micronutrients. Expand
Ascorbic acid attenuates cell stress by activating the fibroblast growth factor 21/fibroblast growth factor receptor 2/adiponectin pathway in HepG2 cells.
TLDR
It is demonstrated that AA may attenuate hepatocyte stress induced by TNFα via activation of the FGF21/FGFR2/adiponectin pathway, which could a novel mechanism of action of AA, and its potential for the treatment of NAFLD/NASH. Expand
Targeting therapeutics to endothelium: are we there yet?
TLDR
Preclinical results summarized here suggest that there is hope for successful implementation of endothelial targeting agents in the years to come, as unexpected toxicities may arise with complex delivery systems. Expand
X12N12 (X = Al, B) clusters for protection of vitamin C; molecular modeling investigation
Abstract Since protection of vitamins towards structure destruction is of important strategies in food science, we persuaded to focus on the study of Vitamin C (VC) adsorption on a new class ofExpand
Production and comparative evaluation of leather products from pawpaw (Carica papaya) and banana (Musa acuminata) fruit pulp
TLDR
This research has demonstrated that processing of fruits into fruit leathers will not only minimize postharvest losses but will also create a new variety of value-added products with higher nutritional value potential compared to its fresh fruits. Expand

References

SHOWING 1-10 OF 67 REFERENCES
Vitamins C and E to prevent complications of pregnancy-associated hypertension.
TLDR
Vitamin C and E supplementation initiated in the 9th to 16th week of pregnancy in an unselected cohort of low-risk, nulliparous women did not reduce the rate of adverse maternal or perinatal outcomes related to pregnancy-associated hypertension. Expand
Vitamins C and E and the risks of preeclampsia and perinatal complications
TLDR
There were no significant differences between the vitamin and placebo groups in the risk of preeclampsia, death or serious outcomes in the infants, and delivering an infant whose birth weight was below the 10th percentile for gestational age. Expand
Vitamin E and C in preeclampsia.
  • S. Kharb
  • Medicine
  • European journal of obstetrics, gynecology, and reproductive biology
  • 2000
TLDR
In patients with preeclampsia antioxidant nutrients may be utilized to a greater extent to counteract free radical-mediated cell disturbances, resulting in a reduction in serum antioxidant levels. Expand
Vitamins C and E and the risks of preeclampsia and perinatal complications.
TLDR
Benefits of supplementation with vitamins C and E during pregnancy do not reduce the risk of preeclampsia in nulliparous women, therisk of intrauterine growth restriction, or the Risk of death or other serious outcomes in their infants. Expand
Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans.
  • A. Carr, B. Frei
  • Medicine
  • The American journal of clinical nutrition
  • 1999
TLDR
The totality of the reviewed data suggests that an intake of 90-100 mg vitamin C/d is required for optimum reduction of chronic disease risk in nonsmoking men and women, suggesting a new RDA of 120 mg vitaminC/d. Expand
Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial
TLDR
Concomitant supplementation with vitamin C and vitamin E does not prevent pre-eclampsia in women at risk, but does increase the rate of babies born with a low birthweight, and use of these high-dose antioxidants is not justified in pregnancy. Expand
Does supplemental vitamin C increase cardiovascular disease risk in women with diabetes?
TLDR
A high vitamin C intake from supplements is associated with an increased risk of cardiovascular disease mortality in postmenopausal women with diabetes. Expand
Vitamin C and the Risk of Preeclampsia— Results from Dietary Questionnaire and Plasma Assay
TLDR
The results would suggest that current public health efforts to increase intake of fruits and vegetables rich in vitamin C and other antioxidants may reduce the risk of preeclampsia. Expand
Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial
TLDR
Multicentre trials are needed to show whether vitamin supplementation affects the occurrence of pre-eclampsia in low-risk women and to confirm the results in larger groups of high- risk women from different populations. Expand
A critical review of vitamin C for the prevention of age-related cognitive decline and Alzheimer's disease.
TLDR
Overall, there is a large body of evidence that maintaining healthy vitamin C levels can have a protective function against age-related cognitive decline and Alzheimer's disease, but avoiding vitamin C deficiency is likely to be more beneficial than taking supplements on top of a normal, healthy diet. Expand
...
1
2
3
4
5
...