Vitamin B6 modulates transcriptional activation by multiple members of the steroid hormone receptor superfamily.

@article{Allgood1992VitaminBM,
  title={Vitamin B6 modulates transcriptional activation by multiple members of the steroid hormone receptor superfamily.},
  author={Victoria E. Allgood and John A. Cidlowski},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 6},
  pages={
          3819-24
        }
}
Recent studies have shown that vitamin B6 modulates transcriptional activation by the human glucocorticoid receptor in HeLa S3 cells. We have now examined the possibility that vitamin B6 might similarly influence transcriptional activation by the glucocorticoid receptor in other cell types, as well as gene expression mediated by other members of the steroid hormone receptor superfamily. We show that elevated vitamin B6 concentrations suppress by 40-65% the level of transcription mediated… 
Modulation of steroid receptor‐mediated gene expression by vitamin B6
  • D. Tully, V. Allgood, J. Cidlowski
  • Biology, Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1994
TLDR
Findings — that the vitamin B6 nutritional status of cells modulates their capacity to respond to steroid hormones — impose an additional level of cell‐specific control over steroid hormone regulation of gene expression and will serve as the focal point for this review.
Vitamin B6 Modulation of Steroid Receptor-mediated Gene Expression
Steroid hormones regulate many physiological processes in tissues and cell types throughout the body, including such fundamental biological processes as growth, development, reproduction, regulation
VITAMIN B6 MODULATION OF GENE EXPRESSION
TLDR
Findings that vitamin B 6 acts as a physiological modulator of gene expression add a new dimension to the hitherto-recognized function of vitamin B 7 as a cofactor of enzyme action.
Modulation of gene expression by vitamin B6
  • T. Oka
  • Biology, Medicine
    Nutrition Research Reviews
  • 2001
TLDR
Findings that vitamin B 6 acts as a physiological modulator of gene expression add a new dimension to the hitherto recognized function of vitamin B6 as a cofactor of enzyme action.
Modulation of gene expression by vitamin B6
The physiologically active form of vitamin B6, pyridoxal 5 -phosphate (PLP), is known to function as a cofactor in many enzymic reactions in amino acid metabolism. Recent studies have shown that,
Modulation of gene expression by vitamin B 6
The physiologically active form of vitamin B6, pyridoxal 5 -phosphate (PLP), is known to function as a cofactor in many enzymic reactions in amino acid metabolism. Recent studies have shown that,
[Vitamin B6 and cancer: from clinical data to molecularly mechanisms].
TLDR
Mechanistic and clinical data justify further studies to decipher the mechanism of action of vitamin B6 and its clinical interest in combination with molecules typically used in chemotherapy or hormonal therapy.
Pyridoxal 5'-phosphate modulates expression of cytosolic aspartate aminotransferase gene by inactivation of glucocorticoid receptor.
TLDR
Observations suggest that pyridoxal 5'-phosphate modulates cAST gene expression by inactivating the binding activity of glucocorticoid receptor to glucoc Corticoid-responsive elements.
Vitamin B6 conjugation to nuclear corepressor RIP140 and its role in gene regulation.
TLDR
A new physiological role of vitamin B6 in gene regulation by PLP conjugation to a transcriptional coregulator is uncovered, which represents a new function of an old form of protein post-translational modification that has important biological consequences.
Vitamin B6 suppresses serine protease inhibitor 3 expression in the colon of rats and in TNF-α-stimulated HT-29 cells.
TLDR
Vitamin B6 suppressed SPI-3 expression in the colon of rats and in TNF-α-stimulated HT-29 cells, and a possible role of vitamin B6 in the regulation of protein ubiquitination was shown.
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