Vitamin B6 modulates transcriptional activation by multiple members of the steroid hormone receptor superfamily.

@article{Allgood1992VitaminBM,
  title={Vitamin B6 modulates transcriptional activation by multiple members of the steroid hormone receptor superfamily.},
  author={V. E. Allgood and J. Cidlowski},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 6},
  pages={
          3819-24
        }
}
  • V. E. Allgood, J. Cidlowski
  • Published 1992
  • Biology, Medicine
  • The Journal of biological chemistry
  • Recent studies have shown that vitamin B6 modulates transcriptional activation by the human glucocorticoid receptor in HeLa S3 cells. We have now examined the possibility that vitamin B6 might similarly influence transcriptional activation by the glucocorticoid receptor in other cell types, as well as gene expression mediated by other members of the steroid hormone receptor superfamily. We show that elevated vitamin B6 concentrations suppress by 40-65% the level of transcription mediated… CONTINUE READING
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