Vitamin B6 deficiency, genome instability and cancer.

  title={Vitamin B6 deficiency, genome instability and cancer.},
  author={Xia-Yu Wu and Lin Lu},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  volume={13 11},
  • Xia-Yu Wu, Lin Lu
  • Published 2012 in
    Asian Pacific journal of cancer prevention…
Vitamin B6 functions as a coenzyme in >140 enzymatic reactions involved in the metabolism of amino acids, carbohydrates, neurotransmitters, and lipids. It comprises a group of three related 3-hydroxy-2-methyl-pyrimidine derivatives: pyridoxine (PN), pyridoxal (PL), pyridoxamine (PM) and their phosphorylated derivatives [pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phosphate (PMP)], In the folate metabolism pathway, PLP is a cofactor for the mitochondrial and cytoplasmic isozymes of serine… CONTINUE READING