Vitamin B12 deficiency in Caenorhabditis elegans results in loss of fertility, extended life cycle, and reduced lifespan☆

@inproceedings{Bito2013VitaminBD,
  title={Vitamin B12 deficiency in Caenorhabditis elegans results in loss of fertility, extended life cycle, and reduced lifespan☆},
  author={Tomohiro Bito and Yohei Matsunaga and Yukinori Yabuta and Tsuyoshi Kawano and Fumio Watanabe},
  booktitle={FEBS open bio},
  year={2013}
}
Vitamin B12 (B12) deficiency has been linked to developmental disorders, metabolic abnormalities, and neuropathy; however, the mechanisms involved remain poorly understood. Caenorhabditis elegans grown under B12-deficient conditions for five generations develop severe B12 deficiency associated with various phenotypes that include decreased egg-laying capacity (infertility), prolonged life cycle (growth retardation), and reduced lifespan. These phenotypes resemble the consequences of B12… CONTINUE READING
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