Vitamin B12 as a carrier of peptide nucleic acid (PNA) into bacterial cells

@inproceedings{Rwnicki2017VitaminBA,
  title={Vitamin B12 as a carrier of peptide nucleic acid (PNA) into bacterial cells},
  author={Marcin R{\'o}wnicki and Monika Wojciechowska and Aleksandra J Wierzba and Jakub Czarnecki and Dariusz Bartosik and Dorota Gryko and Joanna Trylska},
  booktitle={Scientific Reports},
  year={2017}
}
Short modified oligonucleotides targeted at bacterial DNA or RNA could serve as antibacterial agents provided that they are efficiently taken up by bacterial cells. However, the uptake of such oligonucleotides is hindered by the bacterial cell wall. To overcome this problem, oligomers have been attached to cell-penetrating peptides, but the efficiency of delivery remains poor. Thus, we have investigated the ability of vitamin B12 to transport peptide nucleic acid (PNA) oligomers into cells of… CONTINUE READING
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