Vitamin B12 Deficiency: an Update for the General Paediatrician

  title={Vitamin B12 Deficiency: an Update for the General Paediatrician},
  author={Joey K Smith and David Coman},
  journal={Pediatrics \& Therapeutics},
Vitamin B12 deficiency is an important and possibly under recognised cause of neurological morbidity in infants. The causes of infantile vitamin B12 deficiency are heterogeneous, ranging from dietary deficiency in a breast feeding mother to specific inborn errors of metabolism. In this brief review we discuss the clinical presentations of vitamin B12 deficiency, provide a practical approach to the investigation and management of infantile vitamin B12 deficiency, and consider specific… 
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Early detection by screening in infants with suggestive clinical presentations, using urine methylmalonic acid/plasma homocysteine as screening tools, maternal screening during pregnancy, and long-term neurodevelopmental follow-up are recommended.
Department of Pediatrics, Medicine Hospital, Biruni University İstanbul, Turkey. Department of Obstetrics and Gynecology, Medicine Hospital, Biruni University İstanbul, Turkey. Abstract Aim: Vitamin
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Anyai és újszülöttkori B12-vitamin-hiány felismerése kiterjesztett újszülöttkori szűréssel
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Vitamin B12 deficiency in a breast fed infant.
Treatment of the infant with vitamin B12 resulted in a rapid clinical and haematological improvement and represents an unusual presentation of pernicious anaemia.
Clinical manifestations of infants with nutritional vitamin B12 deficiency due to maternal dietary deficiency
Hematological, neurological and gastrointestinal characteristics of nutritional vitamin B12 deficiency are presented in infants due to maternal diet without adequate protein of animal origin.
Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms.
This review summarizes the current knowledge concerning infantile vitamin B(12) deficiency, including a pooled analysis of case studies of infants born to mothers with untreated pernicious anemia or a strict vegetarian lifestyle and a discussion of the mechanisms that may underlie the manifestations of deficiency.
Neonatal vitamin B12 deficiency secondary to maternal subclinical pernicious anemia: identification by expanded newborn screening.
A neonate with elevated propionylcarnitine on the newborn screen was found to have methylmalonic acidemia due to vitamin B(12) deficiency, allowing prompt treatment and prevention of potential sequelae.
Maternal vegan diet causing a serious infantile neurological disorder due to vitamin B12 deficiency
Biochemical investigations revealed severe methylmalonic aciduria and homocystinuria in the patient, slight methylmalonal aciduria inThe mother and low concentrations of serum vitamin B12 in both patient and mother.
Infantile megaloblastosis secondary to maternal vitamin B12 deficiency.
Any infant which fails to thrive, with progressive neurological deterioration and haematological cytopenias should have their vitamin B12 and folate status rapidly assessed, one of the few potentially reversible causes of failure to thrive and neurological deterioration.
Retardation of myelination due to dietary vitamin B12 deficiency: cranial MRI findings
The case of a 14 1/2-month-old child of strictly vegetarian parents who presented with severe psychomotor retardation, which was concluded that this myelination retardation was due to insufficient intake of vitamin B 12 and vitamin B12 therapy was instituted.
Persistence of neurological damage induced by dietary vitamin B-12 deficiency in infancy
It is concluded that infantile vitamin B-12 deficiency induced by maternal vegan diets may cause lasting neurodisability even though vitamin B -12 supplementation leads to rapid resolution of cerebral atrophy and electroencephalographic abnormality.
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Nearly one half of the infants with vitamin B12 deficiency exhibit abnormal movements, variously described as tremors, twitches, chorea, or myoclonus, which can appear several days after the start of treatment when the infant is improving.
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This review highlights the features of cobalamin and folate deficiency and insufficiency that are particular to children and should be part of the investigation of failure to thrive, neurological disorders, and unexplained anemia or cytopenias in children.