Vitamin B12, folic acid, and the nervous system

@article{Reynolds2006VitaminBF,
  title={Vitamin B12, folic acid, and the nervous system},
  author={Edward Reynolds},
  journal={The Lancet Neurology},
  year={2006},
  volume={5},
  pages={949-960}
}
  • E. Reynolds
  • Published 1 November 2006
  • Medicine
  • The Lancet Neurology

Figures and Tables from this paper

[Neurological pathology associated with vitamin B group deficiency: thiamine, folate and cobalamin].

This review addresses the most relevant neurological diseases associated with thiamine, folate and cobalamin deficiency, and focuses especially combined subacute degeneration and Wernicke-Korsakoff syndrome.

Vitamin B6, B9, and B-12

The Effects of Vitamin B in Depression.

Evidence is provided that vitamin B contributes to the complexity of depressive symptoms and the causes of depression and the neurochemical pathways in depression are discussed.

Deficiency of vitamin B12 and development of Geriatric syndromes

Vitamin B12 deficiency or cyanocobalamin is a common condition in the elderly. It is repeatedly overlooked due to multiple clinical manifestations that can affect the blood, neurological,

Vitamin B12 deficit and development of geriatric syndromes

Vitamin B12 deficiency or cyanocobalamin is a common condition in the elderly. It is repeatedly overlooked due to multiple clinical manifestations that can affect the blood, neurological,

Vitamin B12 deficit and development of geriatric syndromes

Vitamin B12 deficiency or cyanocobalamin is a common condition in the elderly. It is repeatedly overlooked due to multiple clinical manifestations that can affect the blood, neurological,

A review of vitamin B12

Involvements of Hyperhomocysteinemia in Neurological Disorders

How much is known about the possible role of HHCY in neurodegenerative disease is summarized.
...

References

SHOWING 1-10 OF 186 REFERENCES

Folic acid: nutritional biochemistry, molecular biology, and role in disease processes.

  • M. Lucock
  • Biology
    Molecular genetics and metabolism
  • 2000
A role for this B vitamin in maintaining good health may extend beyond these clinical conditions to encompass other birth defects, several types of cancer, dementia, affective disorders, Down's syndrome, and serious conditions affecting pregnancy outcome.

Relationship between Serum and Cerebrospinal Fluid Folate

The relationship between serum and CSF folate concentrations in a group of neurological controls, psychiatric patients and drug treated epileptic patients is examined to evaluate the relationship of folate deficiency to nervous system disorders.

Folic acid, ageing, depression, and dementia

  • E. Reynolds
  • Medicine, Psychology
    BMJ : British Medical Journal
  • 2002
Edward Reynolds draws together the evidence that folic acid is important for functioning of the nervous system at all ages, and suggests a link between folic Acid, homocysteine, ageing, depression, and dementia, including Alzheimer's disease and vascular disease.

Inherited Disorders of Folate and Cobalamin

Confirmed inborn errors of folate transport and metabolism include hereditary folate malabsorption (HFM), glutamate formiminotransferase (GFT) deficiency, and methylenetetrahydrofolate reductase

Multiple sclerosis and vitamin B12 metabolism

  • E. Reynolds
  • Medicine, Biology
    Journal of Neuroimmunology
  • 1992

Folate, homocysteine, and negative symptoms in schizophrenia.

Serum folate concentration correlated inversely with the Scale for Assessment of Negative Symptoms total score and was lower in patients with the deficit syndrome than in nondeficit patients, which could reflect several possible mechanisms, including low dietary intake of folate, low GCPII activity, cigarette smoking, and the involvement of folates in the synthesis of neurotransmitters.

Functional vitamin B12 deficiency and Alzheimer disease

A complementary model of oxidative stress–induced hyperhomocystinemia is proposed, suggesting that cerebral oxidative stress augments the oxidation of an intermediate form of vitamin B 12 generated in the methionine synthase reaction, thereby impairing the metabolism of homocysteine.

Autoantibodies to folate receptors in the cerebral folate deficiency syndrome.

Serum from 25 of the 28 patients and 0 of 28 control subjects contained high-affinity blocking autoantibodies against membrane-bound folate receptors that are present on the choroid plexus, which normalized 5MTHF levels in the cerebrospinal fluid and led to clinical improvement.

Functional vitamin B(12) deficiency and Alzheimer disease.

It is suggested that cerebral oxidative stress augments the oxidation of an intermediate form of vitamin B(12) (cob[I]alamin) generated in the methionine synthase reaction, thereby impairing the metabolism of homocysteine.
...