Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.

  title={Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.},
  author={Chenbo Zhang and Jianfeng Luo and Changzheng Yuan and Ding Ding},
  journal={Journal of Alzheimer's disease : JAD},
BACKGROUND Previous studies have indicated that B vitamin deficiencies are an essential cause of neurological pathology. There is a need to provide evidence of the benefit of B vitamins for the prevention of cognitive decline in community-dwelling older adults. OBJECTIVE To examine the association between intake and plasma levels of vitamins B12, B6, and folate and cognitive function in older populations through a systematic review and meta-analysis. METHODS Medline (PubMed), EMBASE, and… 

The preventive efficacy of vitamin B supplements on the cognitive decline of elderly adults: a systematic review and meta-analysis

Vitamin B supplements might delay or maintain the cognitive decline of elderly adults and should be considered as a preventive medication to MCI patients or elderly adults without cognitive impairment, according to the results of meta-analysis.

Cognitive function and vitamin B12 and D in elders from Ecuador

Lower levels of vitamin B12 but not vitamin D levels were associated with cognitive function in a representative group of Ecuadorian elders, and a statically significant non linear interaction was found between vitamin B 12 and age with respect to cognitive function.

A Biological Index to Screen Multi-Micronutrient Deficiencies Associated with the Risk to Develop Dementia in Older Persons from the Community

An index of assessment of micronutritional biological status is a practical tool that may help identify populations with inadequate nutritional status, screen eligible individuals for nutritional prevention in primary care, or for supplementation in preventive trials of dementia.

One-Carbon Metabolism Biomarkers and Risks of Incident Neurocognitive Disorder among Cognitively Normal Older Adults

Low B12, high homocysteine, low B12 in the presence of high folate, and a one-carbon index of hypo-methylation were independently associated with progression to NCD among cognitively normal.

Mechanistic Link between Vitamin B12 and Alzheimer’s Disease

The important role of vitamin B12 in AD is emphasized, which is particularly important, as even in industrialized countries a large proportion of the population might not be sufficiently supplied with vitamin B 12.

Vitamins in Alzheimer’s Disease—Review of the Latest Reports

A properly balanced diet, as well as the use of appropriate supplementation, can contribute to improving the clinical condition of patients with AD.

Folate Related Pathway Gene Analysis Reveals a Novel Metabolic Variant Associated with Alzheimer’s Disease with a Change in Metabolic Profile

An abnormal SNP in methylene tetrahydrofolate dehydrogenase 1 (MTHFD1) was significantly predictive of AD and associated with an increase in tissue glutathione and a strong prediction of susceptibility and disease among the SNPs associated with AD.

The role of biofactors in the prevention and treatment of age‐related diseases

The present demographic changes toward an aging society caused a rise in the number of senior citizens and the incidence and burden of age‐related diseases (such as cardiovascular diseases [CVD],

Impact of the increasing concentrations of selected perfluoroalkyl acids on the observed concentrations of red blood cell folate among US adults aged ≥20 years

  • R. Jain
  • Medicine
    Environmental Science and Pollution Research
  • 2021
In almost consistent fashion, increasing concentrations of PFAAs were associated with decreasing concentrations of RBCF, and Non-Hispanic blacks as compared to non-Hispanic whites and Hispanics had the lowest decreases in RBCf concentrations.

The neuropsychiatric effects of nitrous oxide and low vitamin B12

SUMMARY This narrative review article aims to update knowledge on the neuropsychiatric complications of nitrous oxide use and low vitamin B12. We consider common forms and uses of nitrous oxide (N2O)



Effect of Vitamin B Supplementation on Cognitive Function in the Elderly: A Systematic Review and Meta-Analysis

Raised total plasma homocysteine is associated with an increased risk of cognitive impairment and dementia, although available evidence from randomized controlled trials shows no obvious cognitive benefit of lowering homocy steine using B vitamins.

Does taking vitamin, mineral and fatty acid supplements prevent cognitive decline? A systematic review of randomized controlled trials.

  • X. JiaG. McneillA. Avenell
  • Medicine, Psychology
    Journal of human nutrition and dietetics : the official journal of the British Dietetic Association
  • 2008
There was little evidence of a beneficial effect from taking B vitamins or antioxidant supplements on global cognitive function in later life, and larger-scale randomized controlled trials of longer duration in selected age groups are needed.

Clinical relevance of low serum vitamin B12 concentrations in older people: the Banbury B12 study.

Low vitamin B 12 concentrations are associated with cognitive impairment and missing ankle tendon jerks in older people in the absence of anaemia and large-scale trials of vitamin B12 supplementation are required to assess the clinical significance of these associations.

Low vitamin B-12 status and risk of cognitive decline in older adults.

Low vitamin B-12 status was associated with more rapid cognitive decline, and Randomized trials are required to determine the relevance of vitaminB-12 supplementation for prevention of dementia.

Dietary Folate and Vitamin B12 Intake and Cognitive Decline Among Community-Dwelling Older Persons.

  • E. CarneyT. Canada
  • Medicine
    Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
  • 2006
High intake of folate may be associated with cognitive decline in older persons, and these unexpected findings call for further study of the cognitive implications of high levels of dietary folate in older populations.

B-Vitamin Intake and Biomarker Status in Relation to Cognitive Decline in Healthy Older Adults in a 4-Year Follow-Up Study

Lower dietary and biomarker status of vitamin B6 at baseline predicted a greater than expected rate of cognitive decline over a 4-year period in healthy older adults, suggesting that Vitamin B6 may be an important protective factor in helping maintain cognitive health in ageing.

A randomised controlled trial investigating the effect of vitamin B12 supplementation on neurological function in healthy older people: the Older People and Enhanced Neurological function (OPEN) study protocol [ISRCTN54195799]

A randomized double-blind placebo-controlled trial involving 200 older people aged 75 years or greater to assess whether dietary supplementation with crystalline vitamin B12 will improve electrophysiological indices of neurological function in older people who have biochemical evidence of vitamin B 12 insufficiency in the absence of anaemia.

Dietary folate, vitamin B-12, vitamin B-6 and incident Alzheimer’s disease: The cache county memory, health, and aging study

Dietary intake of B-vitamins from food and supplemental sources appears unrelated to incidence of dementia and AD.