Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway.

@article{Katare2010VitaminBA,
  title={Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway.},
  author={Rajesh G Katare and Andrea Caporali and Atsuhiko Oikawa and Marco Meloni and Costanza Emanueli and Paolo Madeddu},
  journal={Circulation. Heart failure},
  year={2010},
  volume={3 2},
  pages={294-305}
}
BACKGROUND The increasing incidence of diabetes mellitus will result in a new epidemic of heart failure unless novel treatments able to halt diabetic cardiomyopathy early in its course are introduced. This study aimed to determine whether the activity of the Akt/Pim-1 signaling pathway is altered at critical stages of diabetic cardiomyopathy and whether supplementation with vitamin B1 analog benfotiamine (BFT) helps to sustain the above prosurvival mechanism, thereby preserving cardiomyocyte… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
39 Extracted Citations
12 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 39 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 12 references

Tissue kal likrein and kinin infusion promotes neovascularization in limb ischemia

  • RS Smith, Jr., L Gao, L Chao, J. Chao
  • 2008

Similar Papers

Loading similar papers…