Vitamin B1 (thiamine) uptake by human retinal pigment epithelial (ARPE-19) cells: mechanism and regulation.

@article{Subramanian2007VitaminB,
  title={Vitamin B1 (thiamine) uptake by human retinal pigment epithelial (ARPE-19) cells: mechanism and regulation.},
  author={V. Sankara Subramanian and Zainab M Mohammed and Andr{\'e}s Molina and Jonathan S. Marchant and Nosratola D. Vaziri and Hamid Said},
  journal={The Journal of physiology},
  year={2007},
  volume={582 Pt 1},
  pages={73-85}
}
Retinal abnormality and visual disturbances occur in thiamine-responsive megaloblastic anaemia (TRMA), an autosomal recessive disorder caused by mutations in the human thiamine transporter-1 (hTHTR-1). Human retinal pigment epithelial cells play a pivotal role in supplying thiamine to the highly metabolically active retina but nothing is known about the… CONTINUE READING