Vitamin B-12 status is inversely associated with plasma homocysteine in young women with C677T and/or A1298C methylenetetrahydrofolate reductase polymorphisms.

@article{Bailey2002VitaminBS,
  title={Vitamin B-12 status is inversely associated with plasma homocysteine in young women with C677T and/or A1298C methylenetetrahydrofolate reductase polymorphisms.},
  author={Lynn B. Bailey and Robert L Duhaney and David R. Maneval and Gail Pa Kauwell and Eoin P. Quinlivan and Steven R. Davis and Aisha Cuadras and Alan D. Hutson and J. Gregory},
  journal={The Journal of nutrition},
  year={2002},
  volume={132 7},
  pages={
          1872-8
        }
}
Methylenetetrahydrofolate reductase (MTHFR) polymorphisms may negatively influence one-carbon metabolism and increase health risks in women of reproductive age. The effect of MTHFR single nucleotide polymorphisms at bp 677 and/or 1298 and differences in folate and vitamin B-12 status on plasma homocysteine concentration in women of reproductive age (20-30 y; n = 186) were investigated. From the multivariate regression model, homozygotes (n = 23) for the C677T MTHFR variant had plasma… CONTINUE READING
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