Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epithelium.

@article{Choi2004VitaminBD,
  title={Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epithelium.},
  author={Sang-Woon Choi and Simonetta Friso and Haifa Ghandour and Pamela J. Bagley and Jacob Selhub and Joel B Mason},
  journal={The Journal of nutrition},
  year={2004},
  volume={134 4},
  pages={
          750-5
        }
}
Derangements of one-carbon metabolism can directly affect the integrity of the genome by producing inappropriate uracil insertion into DNA and by altering patterns of DNA methylation. Vitamin B-12, a one-carbon nutrient, serves as a cofactor in the synthesis of precursors of biological methylation and in nucleotide synthesis. We therefore examined whether vitamin B-12 deficiency can induce these molecular anomalies in the colonic mucosa of rats. Weanling male Sprague-Dawley rats (n = 30) were… 

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