Vitamin A-related compounds, all-trans retinal and retinoic acids, selectively inhibit activities of mammalian replicative DNA polymerases.

Abstract

Retinoic acids, vitamin A-related compounds, are known to be inhibitors of telomerase. We found that fucoxanthin from the sea alga Petalonia bingamiae is a potent inhibitor of mammalian replicative DNA polymerases (i.e., pol alpha, delta and epsilon). Since fucoxanthin is a carotenoid (provitamin A-related) compound, we characterized the biochemical modes… (More)

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@article{Murakami2002VitaminAC, title={Vitamin A-related compounds, all-trans retinal and retinoic acids, selectively inhibit activities of mammalian replicative DNA polymerases.}, author={Chikako Murakami and Masaharu Takemura and Yuichi Sugiyama and Shinji Kamisuki and Hitomi Asahara and Miho Kawasaki and Tomomi Ishidoh and S. F. Linn and Shonen Yoshida and Fumio Sugawara and Hiromi Yoshida and Kengo Sakaguchi and Yoshiyuki Mizushina}, journal={Biochimica et biophysica acta}, year={2002}, volume={1574 1}, pages={85-92} }