Vitamin A potentiation of carbon tetrachloride hepatotoxicity: role of liver macrophages and active oxygen species.

@article{Elsisi1993VitaminAP,
  title={Vitamin A potentiation of carbon tetrachloride hepatotoxicity: role of liver macrophages and active oxygen species.},
  author={Ashraf Elsisi and David L. Earnest and I. Glenn Sipes},
  journal={Toxicology and applied pharmacology},
  year={1993},
  volume={119 2},
  pages={295-301}
}
Pretreatment of rats with large doses of vitamin A (VA) potentiates the hepatotoxicity of CCl4. Because our previous studies indicate that VA treatment does not enhance CCl4 metabolism but does enhance CCl4-induced lipid peroxidation and activates liver Kupffer cells to release increased amounts of oxygen-centered free radicals, the current studies were designed to determine if VA treatment potentiates CCl4-induced liver injury through increased release of reactive oxygen species. Plasma… CONTINUE READING
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