Vitamin A deficiency potentiates carbon tetrachloride‐induced liver fibrosis in rats

@article{Seifert1994VitaminAD,
  title={Vitamin A deficiency potentiates carbon tetrachloride‐induced liver fibrosis in rats},
  author={Wilfried F. Seifert and Anne Bosma and Adriaan Brouwer and Henk F. J. Hendriks and PaulJ.M. Roholl and Rick E. W. van Leeuwen and G C van Thiel-de Ruiter and I Seifert-Bock and Dick L. Knook},
  journal={Hepatology},
  year={1994},
  volume={19}
}
Earlier studies have shown that retinoid administration suppresses the generation of hepatic fibrosis and stimulates its regression in normal (i.e., vitamin A‐sufficient) carbon tetrachloride‐treated rats. This study focuses on the possible role of a marginal or deficient vitamin A status on carbon tetrachloride‐induced fibrosis. This experimental study in rats shows that vitamin A status, reflected by hepatic retinoid content (retinol and retinyl esters), modulates the development of hepatic… 
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The absence of retinoid-containing HSC lipid droplets does not promote HSC activation but reduces hepatocarcinogenesis.
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TLDR
The aim of this review is to summarize the existing knowledge and hypotheses about vitamin A role and the disease progression in cholestatic liver disease.
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Although most of the data are qualitative observation, vitamin A may ameliorate hepatic fibrosis in the BDL model by restoring vitamin A in the HSCs.
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