Vitamin A and iron supplementation is as efficient as hormonal therapy in constitutionally delayed children

  title={Vitamin A and iron supplementation is as efficient as hormonal therapy in constitutionally delayed children},
  author={Zvi Zadik and Tali Sinai and Amnon Zung and Ram M. Reifen},
  journal={Clinical Endocrinology},
objective  To assess the effect of nutritional supplementation on growth and puberty in constitutionally delayed children. 

Vitamins and Trace Elements are Important for the Integrity of the Endocrine System

  • Z. Zadik
  • Medicine, Biology
    Journal of pediatric endocrinology & metabolism : JPEM
  • 2009
A study conducted in northern Finland looking into the incidence of type 1 diabetes mellitus among a pediatric cohort showed a statistical difference between those with inadequate vitamin D during infancy and childhood and those who received vitamin D supplementation, favoring adequate vitamin D intake as a preventive measure to preventabetes mellitus.

Evidence for hypermetabolism in boys with constitutional delay of growth and maturation.

Boys with CDGM have higher rates of overall energy expenditure compared with age- and size-matched controls, and this increased metabolism may result in impaired tempo of growth.

The Impact of Nutritional Interventions beyond the First 2 Years of Life on Linear Growth: A Systematic Review and Meta-Analysis.

It is suggested that zinc, vitamin A, multiple micronutrients, and protein interventions delivered after 24 mo of age can have a positive effect on linear growth, especially in populations that have experienced growth failure.

Nutritional interventions during adolescence and their possible effects.

This mini review sums up some important findings in this important complex that link between nutrition, nutritional interventions, and pubertal development.

A Double-Blind, Placebo-Controlled Comparison of Letrozole to Oxandrolone Effects upon Growth and Puberty of Children with Constitutional Delay of Puberty and Idiopathic Short Stature

This first randomized controlled clinical trial in CDGD teenage boys with predicted short stature shows that letrozole increases PAH more than oxandrolone and advances pubertal stage and bone mineralization less.

Constitutional Delay of Growth and Puberty: the Patient's Perspective

Evaluating the concerns, knowledge, understanding, and expectations of a group of children with CDGP and their families finds that short stature rather than late puberty is usually the reason for consultation in CDGP.

“Functional Food” for Acceleration of Growth in Short Children Born Small for Gestational Age

Six months of vitamin A, iron and zinc supplementation induces growth acceleration in short children born SGA with subnormal nutrients intake similar to growth hormone therapy.

Reduced Final Height and Inadequate Nutritional Intake in Cow's Milk-Allergic Young Adults.

Nutritional Determinants of the Timing of Puberty.

Evidence for prenatal nutrition, infant feeding practices, and childhood intake of fat, carbohydrate, and micronutrients is inconsistent and secondary analyses of prenatal and early-life randomized nutritional interventions with extended follow-up through peripubertal years would help clarify the role of nutrition.

A Clinical Study on the Treatment of Children's Short Stature with Auxiliary Comprehensive Management Combined with Growth Patch

On the basis of auxiliary comprehensive management combined with growth patch for the treatment of children with ISS, it can effectively increase the height of the children, improve the levels of serum IGF-1 and IGFBP-3, and have significant clinical effects, which is beneficial to the healthy growth of theChildren.



Functional hypothalamic amenorrhoea: a partial and reversible gonadotrophin deficiency of nutritional origin

Assessment in women with FHA and normal body mass index (BMI) and apparently normal daily activities, the degree of impairment of GnRH secretion, its nutritional origin and its reversibility is assessed.

Vitamin A and Beta Carotene Levels in Constitutional Delay of Growth and Puberty

It was concluded that vit A deficiency may play a role in CDGP in developing countries.

Iron and zinc supplementation improves indicators of vitamin A status of Mexican preschoolers.

The results of this study agree with previous observations of a metabolic interaction between zinc and vitamin A and suggest an interaction between iron and Vitamin A metabolism.

Body weight progression and nutritional status of patients with familial short stature with and without constitutional delay in growth.

Rec retrospective weight and growth data and a cross-sectional nutritional assessment suggest that suboptimal nutrition early in infancy may contribute to the course of CDG.

[Evaluation of dietary vitamin A intake in children with and without growth retardation].

This study confirms that annual dietary vitamin A intake can easily be measured in school children and suggests that this intake, relatively deficient in children with short stature, could be correlated with deficient secretion of growth-hormone.

Oxandrolone therapy in constitutionally delayed growth and puberty. Bio-Technology General Corporation Cooperative Study Group.

This randomized, placebo-controlled trial demonstrates that low-dose oxandrolone can increase both height and weight velocity in boys with delayed puberty safely, and was not associated with a greater improvement in psychosocial status compared with the control boys.

Psychosocial correlates of short stature and delayed puberty.

Zinc supplementation increases growth velocity of male children and adolescents with short stature

In Chilean male schoolchildren and adolescents with idiopathic short stature, zinc supplementation increases growth velocity over a 12‐month period.

Concomitant supplemental vitamin A enhances the response to weekly supplemental iron and folic acid in anemic teenagers in urban Bangladesh.

There may be significant health benefits from a program that enhances the nutritional status of iron, folate, and vitamin A in poor urban young women before they become pregnant in urban Bangladesh.