Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance.

@article{Cassani2012VitaminAA,
  title={Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance.},
  author={Barbara Cassani and Eduardo J Villablanca and Jaime De Calisto and Sen Wang and J Rodrigo Mora},
  journal={Molecular aspects of medicine},
  year={2012},
  volume={33 1},
  pages={63-76}
}
The vitamin A (VA) metabolite all-trans retinoic acid (RA) plays a key role in mucosal immune responses. RA is produced by gut-associated dendritic cells (DC) and is required for generating gut-tropic lymphocytes and IgA-antibody-secreting cells (IgA-ASC). Moreover, RA modulates Foxp3(+) regulatory T cell (T(REG)) and Th17 effector T cell differentiation. Thus, although RA could be used as an effective "mucosal adjuvant" in vaccines, it also appears to be required for establishing intestinal… CONTINUE READING
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