Vitamin A and beta-carotene influence the level of benzo[a]pyrene-induced DNA adducts and DNA-repair activities in hamster tracheal epithelium in organ culture.

@article{Wolterbeek1995VitaminAA,
  title={Vitamin A and beta-carotene influence the level of benzo[a]pyrene-induced DNA adducts and DNA-repair activities in hamster tracheal epithelium in organ culture.},
  author={Andr{\'e} P. M. Wolterbeek and R Roggeband and Catharina J A Van Moorsel and Robert A. Baan and Jan Koeman and Victor J. Feron and Alphons A. J. J. L. Rutten},
  journal={Cancer letters},
  year={1995},
  volume={91 2},
  pages={205-14}
}
Although most studies concerning the effect of vitamin A and beta-carotene on chemical carcinogenesis are focused on tumour promotion and progression, these compounds may affect initiation as well. In this study the influence of vitamin A and beta-carotene on unscheduled DNA synthesis (UDS) was investigated in hamster tracheal epithelium in organ culture exposed to benzo[a]pyrene (B[a]P). DNA-repair activities were compared with the level of B[a]P-DNA adducts as measured both by 32P… CONTINUE READING