Vitamin A–Not for Your Eyes Only: Requirement for Heart Formation Begins Early in Embryogenesis

@inproceedings{Zile2010VitaminAF,
  title={Vitamin A–Not for Your Eyes Only: Requirement for Heart Formation Begins Early in Embryogenesis},
  author={Maija H. Zile},
  booktitle={Nutrients},
  year={2010}
}
Vitamin A insufficiency has profound adverse effects on embryonic development. Major advances in understanding the role of vitamin A in vertebrate heart formation have been made since the discovery that the vitamin A active form, all-trans-retinoic acid, regulates many genes, including developmental genes. Among the experimental models used, the vitamin A-deficient avian embryo has been an important tool to study the function of vitamin A during early heart formation. A cluster of retinoic acid… CONTINUE READING
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