Vitamin A, a useful biochemical modulator capable of preventing intestinal damage during methotrexate treatment.

@article{Nagai1993VitaminAA,
  title={Vitamin A, a useful biochemical modulator capable of preventing intestinal damage during methotrexate treatment.},
  author={Yashuharu Nagai and Toshiharu Horie and Shoji Awazu},
  journal={Pharmacology \& toxicology},
  year={1993},
  volume={73 2},
  pages={
          69-74
        }
}
The effects of vitamin A on methotrexate treatment of mice inoculated with L1210 leukaemia cells or sarcoma 180 cells were studied. The small intestine of tumour transplanted mice was severely damaged after methotrexate treatment. Coadministration of vitamin A with methotrexate protected the small intestine from methotrexate-induced damage. The protective effect of vitamin A was histologically and biochemically demonstrated. Further, coadministration of vitamin A did not inhibit in vivo… Expand
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