Vitamin A, a useful biochemical modulator capable of preventing intestinal damage during methotrexate treatment.

@article{Nagai1993VitaminAA,
  title={Vitamin A, a useful biochemical modulator capable of preventing intestinal damage during methotrexate treatment.},
  author={Yashuharu Nagai and Toshiharu Horie and Shoji Awazu},
  journal={Pharmacology \& toxicology},
  year={1993},
  volume={73 2},
  pages={
          69-74
        }
}
The effects of vitamin A on methotrexate treatment of mice inoculated with L1210 leukaemia cells or sarcoma 180 cells were studied. The small intestine of tumour transplanted mice was severely damaged after methotrexate treatment. Coadministration of vitamin A with methotrexate protected the small intestine from methotrexate-induced damage. The protective effect of vitamin A was histologically and biochemically demonstrated. Further, coadministration of vitamin A did not inhibit in vivo… 
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22 Citations

Effect of Vitamin A against Methotrexate-Induced Damage to the Small Intestine in Rats
TLDR
The results confirmed that administration of VA decreased the MTX-induced damage to the small intestine, and this protective effect of VA may have clinical applications in cancer chemotherapy.
Amelioration of methotrexate-induced malabsorption by vitamin A
TLDR
It is found that the coadministration of vitamin A (VA) with MTX protected the small intestine from MTX-induced damage, and it seems likely that VA ameliorates MTx-induced malabsorption.
Antioxidants in cancer therapy; their actions and interactions with oncologic therapies.
TLDR
Evidence reviewed here demonstrates exogenous antioxidants alone produce beneficial effects in various cancers, and except for a few specific cases, animal and human studies demonstrate no reduction of efficacy of chemotherapy or radiation when given with antioxidants.
A study on the possible role of mitochondrial damage reactive nitrogen species and reactive oxygen species in the pathogenesis of methotrexate induced small intestinal damage in the rat
TLDR
It is concluded that MTX causes acute inflammatory changes with damage to the villi and crypts of lieberkhun that may result in decreased nutrient absorption associated with barrier and absorptive dysfunction of the small intestine.
Effect of Methotrexate on the Jejunum of Adult Albino Rat and the Possible Protective Role of Vitamin A: Histological and Immunohistochemical Study
TLDR
It can be concluded that the toxic effect of methotrexate on the jejunum of rats can be partially improved with the concomitant use of vitamin A.
Does vitamin A prevent high-dose-methotrexate-induced D-xylose malabsorption in children with cancer?
TLDR
The administration of vitamin A before HDMTX may protect against drug-induced D-xylose malabsorption in children with cancer, and further studies are apparently needed to clarify the full benefits ofitamin A in preventingHDMTX-induced mucosal damage.
Antioxidants and cancer therapy II: quick reference guide.
The previous lengthy review concerning the effects of antioxidant compounds used concurrently with radiotherapy and chemotherapy has been reduced to a reference guide. There are only three presently…
Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage
TLDR
This review will provide an overview of current research as well as identify areas where gaps in knowledge exist in intestinal mucositis through multiple mechanisms including induction of crypt cell death (apoptosis) and cytostasis.
Vitamin A Activation of Transforming Growth Factor-β1 Enhances Porcine Ileum Wound Healing In Vitro
TLDR
It is demonstrated that administration of vitamin A accelerates recovery of normal intestinal wall cytoarchitecture of injured ileum in vitro, without adversely affecting noninjured ilesum.
Studies on Improvement of Gastrointestinal Drug Absorption and Lipid Peroxidation during Drug Metabolism
TLDR
The mechanism of tight junction opening by caprate (C10) that is one of representative enhancers is revealed that C10 releses Ca ion from the intracellular store and that the released Ca ion contracts the actin filament through the activation of myosin light chain kinase.
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References

SHOWING 1-10 OF 24 REFERENCES
Protective effect of vitamin A against the methotrexate-induced damage to small intestine: a study on the crypt cells.
TLDR
Although the oral administration of MTX to rats inhibited DNA synthesis in crypt cells, VA coadministration protected the salvage pathway of pyrimidine synthesis and the de novo purine synthesis in Crypt cells.
Vitamin A protects the small intestine from methotrexate-induced damage in rats.
TLDR
It has been shown histologically, biochemically, physicochemical, physicochemically and physiologically that VA protects the small intestine from the damage induced by MTX.
An in vitro assessment of the effect of cytotoxic drugs upon the intestinal absorption of nutrients in rats.
The effect of oral methotrexate on the rat intestine.
Effects of mitomycin C, 5-fluorouracil and cyclophosphamide on drug absorption, enzyme activities and mucosal lipid composition of intestine.
TLDR
Toxicity to intestinal mucosa was shown to derive from an effect on dividing cells in the crypts because MMC and 5-FU preferentially decreased thymidine kinase activity, and increased mucosal membrane permeability was confirmed at the membrane level.
Effect of methotrexate on drug absorption from the rat small intestine in situ and in vitro.
  • V. Venho
  • Medicine, Chemistry
    Acta pharmacologica et toxicologica
  • 1976
TLDR
The methotrexate-induced reversible decrease in absorption seems to be attributable at least partly to diminished water flux through the intestinal wall, although other mechanisms may also exist.
The effect of repeated oral dosing of methotrexate on its intestinal absorption in the rat.
The pharmacology and clinical use of methotrexate.
METHOTREXATE, the most widely used antimetabolite in cancer chemotherapy, has an essential role in the treatment of such diverse diseases as acute lymphocytic leukemia, non-Hodgkin's lymphoma, oste...
Changes in the mucosa of the small intestine following methotrexate administration or abdominal x-irradiation.
  • G. Altmann
  • Medicine
    The American journal of anatomy
  • 1974
Adult male rats received 5 mg methotrexate daily and were sacrificed 1, 1.5, 2, 2.5 and 3 days after the beginning of the treatment. Other groups received 9,000 rads of abdominal x-radiation and were…
The effect of anti-cancer drugs on the plasma disposition of antipyrine and the biliary excretion of phenolphthalein in the rat.
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