Vitamin A, a useful biochemical modulator capable of preventing intestinal damage during methotrexate treatment.

  title={Vitamin A, a useful biochemical modulator capable of preventing intestinal damage during methotrexate treatment.},
  author={Yashuharu Nagai and Toshiharu Horie and Shoji Awazu},
  journal={Pharmacology \& toxicology},
  volume={73 2},
The effects of vitamin A on methotrexate treatment of mice inoculated with L1210 leukaemia cells or sarcoma 180 cells were studied. The small intestine of tumour transplanted mice was severely damaged after methotrexate treatment. Coadministration of vitamin A with methotrexate protected the small intestine from methotrexate-induced damage. The protective effect of vitamin A was histologically and biochemically demonstrated. Further, coadministration of vitamin A did not inhibit in vivo… 
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Protective effect of vitamin A against the methotrexate-induced damage to small intestine: a study on the crypt cells.
Although the oral administration of MTX to rats inhibited DNA synthesis in crypt cells, VA coadministration protected the salvage pathway of pyrimidine synthesis and the de novo purine synthesis in Crypt cells.
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  • V. Venho
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  • 1976
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    The American journal of anatomy
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