Vitamin A, a useful biochemical modulator capable of preventing intestinal damage during methotrexate treatment.

@article{Nagai1993VitaminAA,
  title={Vitamin A, a useful biochemical modulator capable of preventing intestinal damage during methotrexate treatment.},
  author={Yashuharu Nagai and Toshiharu Horie and Shoji Awazu},
  journal={Pharmacology \& toxicology},
  year={1993},
  volume={73 2},
  pages={
          69-74
        }
}
The effects of vitamin A on methotrexate treatment of mice inoculated with L1210 leukaemia cells or sarcoma 180 cells were studied. The small intestine of tumour transplanted mice was severely damaged after methotrexate treatment. Coadministration of vitamin A with methotrexate protected the small intestine from methotrexate-induced damage. The protective effect of vitamin A was histologically and biochemically demonstrated. Further, coadministration of vitamin A did not inhibit in vivo… Expand
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DHA protected the small intestine of mice from theMTX-induced damage and the permeability of FITC-dextran increased remarkably in the MTX-treated mice and oral administration of docosahexaenoic acid ethyl ester protected thesmall intestine from the increase in the small intestinal permeability. Expand
A study on the possible role of mitochondrial damage reactive nitrogen species and reactive oxygen species in the pathogenesis of methotrexate induced small intestinal damage in the rat
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It can be concluded that the toxic effect of methotrexate on the jejunum of rats can be partially improved with the concomitant use of vitamin A. Expand
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The administration of vitamin A before HDMTX may protect against drug-induced D-xylose malabsorption in children with cancer, and further studies are apparently needed to clarify the full benefits ofitamin A in preventingHDMTX-induced mucosal damage. Expand
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Evaluating the damage to the small intestine of mice caused by MTX administration revealed that MTX treatment disorders the paracellular barrier function of the small intestinal epithelium, resulting in increased permeation of nonabsorbable markers via the parACEllular pathway of theSmall intestinal mucosa. Expand
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TLDR
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