Vitamin C

@article{Linster2007VitaminC,
  title={Vitamin C},
  author={Carole L. Linster and Emile Van Schaftingen},
  journal={The FEBS Journal},
  year={2007},
  volume={274}
}
Vitamin C, a reducing agent and antioxidant, is a cofactor in reactions catalyzed by Cu+‐dependent monooxygenases and Fe2+‐dependent dioxygenases. It is synthesized, in vertebrates having this capacity, from d‐glucuronate. The latter is formed through direct hydrolysis of uridine diphosphate (UDP)‐glucuronate by enzyme(s) bound to the endoplasmic reticulum membrane, sharing many properties with, and most likely identical to, UDP‐glucuronosyltransferases. Non‐glucuronidable xenobiotics… 
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  • 2021
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TLDR
Radiotracer experiments with 3H‐myo‐inositol revealed that the mutants in glucuronokinase1 accumulate only glucuronic acid and incorporate less metabolite into cell wall polymers, suggesting that Arabidopsis cannot efficiently use glucURonic acid for AsA biosynthesis.
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TLDR
FMN is an essential cofactor for enzyme activity and binds to TcGAL non-covalently, and a histidine residue located within the N-terminal flavin-binding motif has been shown to be crucial for cofactor binding.
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    Free radical biology & medicine
  • 2018
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Novel enzymes were identified that generate L-ascorbic acid directly via oxidation of L-sorbosone, an intermediate of the bio-oxidation of D-sorbitol to 2KGA, obviating the need for chemical rearrangement of2KGA.
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TLDR
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TLDR
The increasing knowledge of the functions of ascorbate and of its molecular sites of action can mechanistically substantiate a place for asCorbate in the treatment of various diseases.
Vitamin C in Plants: From Functions to Biofortification
TLDR
In this review, the multiple roles of vitamin C in plant physiology as well as the regulation of its content, through biosynthetic or recycling pathways, are analyzed and attention is paid to the strategies that have been used to increase the content of vitamins C in crops.
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TLDR
The sensitivity of UDP‐glucuronidase to metyrapone and other stimulatory xenobiotics was lost in washed microsomes, even in the presence of ATP‐Mg, but it could be restored by adding a heated liver high‐speed supernatant or CoASH.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
Ascorbic acid, or vitamin C, is a primary antioxidant in plasma and within cells, but it can also interact with the plasma membrane by donating electrons to the α‐tocopheroxyl radical and a trans‐plasma membrane oxidoreductase activity, and ascorbate is the preferred electron donor within cells.
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