Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival.

@article{Takano2011VitalRO,
  title={Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival.},
  author={Jiro Takano and Naomi Mihira and Ryo Fujioka and Emi Hosoki and Athar H Chishti and Takaomi C Saido},
  journal={Molecular and cellular biology},
  year={2011},
  volume={31 19},
  pages={4097-106}
}
Although the calpain-calpastatin system has been implicated in a number of pathological conditions, its normal physiological role remains largely unknown. To investigate the functions of this system, we generated conventional and conditional calpain-2 knockout mice. The conventional calpain-2 knockout embryos died around embryonic day 15, preceded by cell death associated with caspase activation and DNA fragmentation in placental trophoblasts. In contrast, conditional knockout mice in which… CONTINUE READING

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