Vital organ blood flow during hyperdynamic sepsis.

@article{DiGiantomasso2003VitalOB,
  title={Vital organ blood flow during hyperdynamic sepsis.},
  author={David Di Giantomasso and Clive N. May and Rinaldo Bellomo},
  journal={Chest},
  year={2003},
  volume={124 3},
  pages={
          1053-9
        }
}
OBJECTIVES To develop a nonlethal model of hyperdynamic sepsis, and to measure vital organ blood flows in this setting. DESIGN Randomized crossover animal study. SETTING Animal laboratory of university-affiliated physiology institute. SUBJECTS Seven Merino cross sheep. INTERVENTIONS Surgical implantation of transit-time flow probes around sagittal sinus and circumflex coronary, superior mesenteric, and left renal arteries, and of an electromagnetic flow probe around the ascending aorta… 
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165 Citations
Highly Influential Citations
4
Background Citations
42
Methods Citations
2
Results Citations
6

165 Citations

Citation Type

Citation Type

The effect of normal saline resuscitation on vital organ blood flow in septic sheep
TLDR
In hyperdynamic sepsis resuscitation with normal saline increases central venous pressure, cardiac output, mesenteric blood flow, urine output, creatinine clearance, and fractional excretion of sodium despite a lack of effect on renal blood flow.
Angiotensin II in experimental hyperdynamic sepsis
TLDR
In early experimental hypotensive hyperdynamic sepsis, intravenous angiotensin II infusion decreased renal blood while inducing a marked increase in urine output and normalizing creatinine clearance.
Early Hyperdynamic Sepsis Alters Coronary Blood Flow Regulation in Porcine Fecal Peritonitis
TLDR
Autoregulation and metabolic blood flow regulation were both impaired in the coronary circulation during experimental hyperdynamic sepsis, although endothelial vasodilatory response was preserved.
Renal blood flow in experimental septic acute renal failure.
TLDR
Reduced renal blood flow (RBF) is considered central to the pathogenesis of septic acute renal failure (ARF) and a marked increase in RBF and with renal vasodilatation was associated with hyperdynamic sepsis and ARF.
Research Angiotensin II in experimental hyperdynamic sepsis
TLDR
Hyperdynamic sepsis was induced by the intravenous administration of live E. coli in conscious ewes after chronic instrumentation with flow probes around the aorta and the renal, mesenteric, coronary and iliac arteries and there were no major effects of Ang II on other regional blood flows.
Bolus hypertonic or normal saline resuscitation in gram-negative sepsis: systemic and regional haemodynamic effects in sheep.
  • L. Wan, R. Bellomo, C. May
  • Medicine, Biology
    Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine
  • 2011
TLDR
In septic sheep, bolus resuscitation with HTS had similar systemic haemodynamic effects as NS and both increased cardiac output and mesenteric blood flow during the first hour compared with control, but only transiently increased with NS (P < 0.05), while NS transiently decreased total and renal oxygen delivery.
Effects of Renal Denervation on Regional Hemodynamics and Kidney Function in Experimental Hyperdynamic Sepsis
TLDR
In experimental hyperdynamic sepsis, renal denervation was associated with greater hypotension and a loss of the initial diuresis, but no significant change in creatinine clearance.
The Systemic and Regional Hemodynamic Effects of Phenylephrine in Sheep Under Normal Conditions and During Early Hyperdynamic Sepsis
TLDR
In sheep with early hyperdynamic sepsis, phenylephrine, at a dose that restored MAP, increased stroke volume and renal bloodflow while decreasing HR and coronary bloodflow but not mesenteric bloodflow.
Cortical and Medullary Tissue Perfusion and Oxygenation in Experimental Septic Acute Kidney Injury
TLDR
In a large animal model of hyperdynamic sepsis, renal hyperemia was associated with preserved cortical oxygenation and perfusion, but decreasedMedullary hypoxia due to intrarenal blood flow redistribution may be one of the factors causing acute kidney injury in sepsi.
Transfer function analysis of baroreflex function in a rabbit model of endotoxic shock
TLDR
The results highlight the potential value of frequency spectrum analysis combined with transfer function analysis of cardiovascular variability in the assessment of autonomic and baroreflex-related changes associated with endotoxic shock.
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