Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex.

@article{Lansdon2010VisualizingTM,
  title={Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex.},
  author={E. Lansdon and D. Samuel and L. Lagpacan and K. Brendza and K. White and M. Hung and Xiaohong Liu and C. Boojamra and R. Mackman and T. Cihl{\'a}ř and A. Ray and M. Mcgrath and S. Swaminathan},
  journal={Journal of molecular biology},
  year={2010},
  volume={397 4},
  pages={
          967-78
        }
}
GS-9148 ([5-(6-amino-purin-9-yl)-4-fluoro-2,5-dihydro-furan-2-yloxymethyl]-phosphonic acid) is a dAMP (2'-deoxyadenosine monophosphate) analog that maintains its antiviral activity against drug-resistant HIV. Crystal structures for HIV-1 reverse transcriptase (RT) bound to double-stranded DNA, ternary complexes with either GS-9148-diphosphate or 2'-deoxyadenosine triphosphate (dATP), and a post-incorporation structure with GS-9148 translocated to the priming site were obtained to gain insight… Expand
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