Visualizing production of beta interferon by astrocytes and microglia in brain of La Crosse virus-infected mice.

@article{Kallfass2012VisualizingPO,
  title={Visualizing production of beta interferon by astrocytes and microglia in brain of La Crosse virus-infected mice.},
  author={Carsten Kallfass and Andreas Ackerman and Stefan Lienenklaus and Siegfried Weiss and Bernd Heimrich and Peter Staeheli},
  journal={Journal of virology},
  year={2012},
  volume={86 20},
  pages={
          11223-30
        }
}
Beta interferon (IFN-β) is a major component of innate immunity in mammals, but information on the in vivo source of this cytokine after pathogen infection is still scarce. To identify the cell types responsible for IFN-β production during viral encephalitis, we used reporter mice that express firefly luciferase under the control of the IFN-β promoter and stained organ sections with luciferase-specific antibodies. Numerous luciferase-positive cells were detected in regions of La Crosse virus… CONTINUE READING
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