Visualizing preference of G protein-coupled receptor kinase 3 for the process of kappa-opioid receptor sequestration.

@article{Schulz2002VisualizingPO,
  title={Visualizing preference of G protein-coupled receptor kinase 3 for the process of kappa-opioid receptor sequestration.},
  author={R{\"u}diger Schulz and Andrea Wehmeyer and Karin Schulz},
  journal={Molecular pharmacology},
  year={2002},
  volume={61 6},
  pages={1444-52}
}
G protein-coupled receptor kinases (GRKs) phosphorylate opioid receptors, which eventually results in receptor sequestration. With respect to kappa-opioid receptors, it is known that internalization occurs in a species-specific manner. That is, the agonist-occupied human kappa-receptors will sequester whereas murine receptors fail to do so. This investigation concentrates on the internalization of kappa-opioid receptors, employing laser scanning microscopy as a major technique to examine… CONTINUE READING

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