Visualizing preference of G protein-coupled receptor kinase 3 for the process of kappa-opioid receptor sequestration.


G protein-coupled receptor kinases (GRKs) phosphorylate opioid receptors, which eventually results in receptor sequestration. With respect to kappa-opioid receptors, it is known that internalization occurs in a species-specific manner. That is, the agonist-occupied human kappa-receptors will sequester whereas murine receptors fail to do so. This… (More)


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