Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus.

@article{Graham2002VisualizingHL,
  title={Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus.},
  author={Robert R. Graham and Ward A. Ortmann and Carl D. Langefeld and Damini Jawaheer and Scott A Selby and Peter R Rodine and Emily C. Baechler and Kristine E Rohlf and Katherine B Shark and Karl J Espe and Linda E. Green and Rajan P. Nair and Philip E Stuart and James T. Elder and Richard L. King and Kathy L. Moser and Patrick M Gaffney and Teodorica L. Bugawan and Henry A. Erlich and Stephen S. Rich and Peter K. Gregersen and Timothy W. Behrens},
  journal={American journal of human genetics},
  year={2002},
  volume={71 3},
  pages={543-53}
}
Human leukocyte antigen (HLA) class I and class II alleles are implicated as genetic risk factors for many autoimmune diseases. However, the role of the HLA loci in human systemic lupus erythematosus (SLE) remains unclear. Using a dense map of polymorphic microsatellites across the HLA region in a large collection of families with SLE, we identified three distinct haplotypes that encompassed the class II region and exhibited transmission distortion. DRB1 and DQB1 typing of founders showed that… CONTINUE READING

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