Visualizing detergent resistant domains in model membranes with atomic force microscopy.

@article{Rinia2001VisualizingDR,
  title={Visualizing detergent resistant domains in model membranes with atomic force microscopy.},
  author={Hilde A. Rinia and Margot M. E. Snel and J P van der Eerden and Ben de Kruijff},
  journal={FEBS letters},
  year={2001},
  volume={501 1},
  pages={
          92-6
        }
}
Evidence is accumulating that in cell membranes microdomains exist, also referred to as rafts or detergent resistant membranes. In this study, atomic force microscopy is used to study supported lipid bilayers, consisting of a fluid phosphatidylcholine, sphingomyelin and cholesterol. Domains were visualized of which the morphology and size depended on the cholesterol concentration. The presence of cholesterol was found to induce bilayer coupling. At 30 mol% cholesterol, a change in percolation… CONTINUE READING
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