Visualizing Peripheral Nerve Regeneration by Whole Mount Staining

  title={Visualizing Peripheral Nerve Regeneration by Whole Mount Staining},
  author={Xin-Peng Dun and David B Parkinson},
  booktitle={PloS one},
Peripheral nerve trauma triggers a well characterised sequence of events both proximal and distal to the site of injury. Axons distal to the injury degenerate, Schwann cells convert to a repair supportive phenotype and macrophages enter the nerve to clear myelin and axonal debris. Following these events, axons must regrow through the distal part of the nerve, re-innervate and finally are re-myelinated by Schwann cells. For nerve crush injuries (axonotmesis), in which the integrity of the nerve… CONTINUE READING
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