Visualizing HIPPO Signaling Components in Mouse Early Embryonic Development.

  title={Visualizing HIPPO Signaling Components in Mouse Early Embryonic Development.},
  author={Tristan Frum and Amy Ralston},
  journal={Methods in molecular biology},
The HIPPO signaling pathway plays an early and essential role in mammalian embryogenesis. The earliest known roles for HIPPO signaling during mouse development include segregating fetal and extraembryonic lineages and establishing the pluripotent progenitors of embryonic stem (ES) cells. In the mouse early embryo, HIPPO signaling responds to multiple cell biological inputs, including cell polarization, cytoskeleton, and cell environment, to influence gene expression and the first cell fate… CONTINUE READING

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