Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal

@article{Kiefer1998VisualizingDR,
  title={Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal},
  author={James R. Kiefer and Chen Mao and Jeffrey C. Braman and Lorena S. Beese},
  journal={Nature},
  year={1998},
  volume={391},
  pages={304-307}
}
DNA polymerases copy DNA templates with remarkably high fidelity, checking for correct base-pair formation both at nucleotide insertion and at subsequent DNA extension steps. Despite extensive biochemical, genetic and structural studies, the mechanism by which nucleotides are correctly incorporated is not known. Here we present high-resolution crystal structures of a thermostable bacterial (Bacillus stearothermophilus) DNA polymerase I large fragment with DNA primer templates bound productively… CONTINUE READING
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