Visualizing Changes in Cdkn1c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults

@inproceedings{Pette2017VisualizingCI,
  title={Visualizing Changes in Cdkn1c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults},
  author={Mathew Van de Pette and Allifia Abbas and Amelie Feytout and Gr{\'a}inne McNamara and Ludovica Bruno and Wilson To and Andrew Dimond and Alessandro Sardini and Zoe Webster and James A. Mcginty and Eleanor J. Paul and Mark A. Ungless and Paul M. W. French and Dominic J. Withers and Anthony G Uren and Anne C Ferguson-Smith and Matthias Merkenschlager and Rosalind M. John and Amanda G Fisher},
  booktitle={Cell reports},
  year={2017}
}
Imprinted genes are regulated according to parental origin and can influence embryonic growth and metabolism and confer disease susceptibility. Here, we designed sensitive allele-specific reporters to non-invasively monitor imprinted Cdkn1c expression in mice and showed that expression was modulated by environmental factors encountered in utero. Acute exposure to chromatin-modifying drugs resulted in de-repression of paternally inherited (silent) Cdkn1c alleles in embryos that was temporary and… CONTINUE READING
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