Visualizing Biological Copper Storage: The Importance of Thiolate‐Coordinated Tetranuclear Clusters


Bacteria possess cytosolic proteins (Csp3s) capable of binding large quantities of copper and preventing toxicity. Crystal structures of a Csp3 plus increasing amounts of CuI provide atomic-level information about how a storage protein loads with metal ions. Many more sites are occupied than CuI equiv added, with binding by twelve central sites dominating… (More)
DOI: 10.1002/anie.201703107