Visualization of tyrosinase activity in melanoma cells by a BODIPY-based fluorescent probe.

  title={Visualization of tyrosinase activity in melanoma cells by a BODIPY-based fluorescent probe.},
  author={Tae-Il Kim and Jihye Park and Seonhwa Park and Yongdoo Choi and Youngmi Kim},
  journal={Chemical communications},
  volume={47 47},
We have presented a fluorescent probe 1 that exhibits a fluorescence turn-on signal upon reaction with tyrosinase, and we show that it is readily employed for the assessment of tyrosinase activity and tyrosinase inhibitor activity in buffered aqueous solution, and further utilized for the visualization of endogenous tyrosinase activity in living melanoma cells. 
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Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future
  • Y. KimH. Uyama
  • Chemistry, Medicine
    Cellular and Molecular Life Sciences CMLS
  • 2005
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