Visualization of tumor heterogeneity in neuroendocrine tumors by positron emission tomography

@article{Lapa2015VisualizationOT,
  title={Visualization of tumor heterogeneity in neuroendocrine tumors by positron emission tomography},
  author={Constantin Lapa and Rudolf A. Werner and Ken Herrmann},
  journal={Endocrine},
  year={2015},
  volume={51},
  pages={556-557}
}
A 50-year-old woman was diagnosed 15 months ago with a well-differentiated neuroendocrine tumor (NET) of the pancreatic tail (Ki-67: 10 %) and synchronous liver metastases. Consecutively, systemic treatment with octreotide was initiated. Due to progression, 2nd line treatment with peptide receptor radionuclide therapy (PRRT) using the Lu-labeled somatostatin analog DOTA-D-Phe1-Tyr3-octreotide (DOTATOC) was initiated. After three cycles of PRRT, somatostatin receptor (SSTR)-based positron… 
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References

SHOWING 1-7 OF 7 REFERENCES
Performance of (18)fluorodeoxyglucose-positron emission tomography and somatostatin receptor scintigraphy for high Ki67 (≥10%) well-differentiated endocrine carcinoma staging.
TLDR
Results suggest that FDG-PET is more sensitive than the SRS for high Ki67 WDEC staging, and a statistical trend was found between Ki67 value and tumor slope.
Prognostic Stratification of Metastatic Gastroenteropancreatic Neuroendocrine Neoplasms by 18F-FDG PET: Feasibility of a Metabolic Grading System
TLDR
The feasibility of prognostic 3-grade stratification of metastatic gastroenteropancreatic NENs by whole-body molecular imaging using 18F-FDG PET in inoperable multifocal disease is demonstrated.
Can Complementary 68Ga-DOTATATE and 18F-FDG PET/CT Establish the Missing Link Between Histopathology and Therapeutic Approach in Gastroenteropancreatic Neuroendocrine Tumors?
TLDR
Combined 68Ga-DOTATATE and 18F-FDG PET/CT is helpful in the individual therapeutic approach of GEPNETs and can overcome the shortcomings of histopathologic grading especially in intermediate-grade GEP NETs.
Procedure guidelines for PET/CT tumour imaging with 68Ga-DOTA-conjugated peptides: 68Ga-DOTA-TOC, 68Ga-DOTA-NOC, 68Ga-DOTA-TATE
The aim of these guidelines is to assist nuclear medicine physicians in recommending, performing, reporting and interpreting the results of somatostatin (SST) receptor PET/CT imaging using
Procedure guidelines for PET / CT tumour imaging with 68 GaDOTAconjugated peptides : 68 GaDOTATOC , 68 GaDOTANOC , 68 GaDOTATATE
  • Eur . J . Nucl . Med . Mol . Imaging
  • 2010
68Ga-DOTA-TOC, 68GaDOTA-NOC, 68Ga-DOTA-TATE
  • Eur. J. Nucl. Med. Mol. Imaging 37, 2004–2010
  • 2010