Visualization of transient encounter complexes in protein–protein association

@article{Tang2006VisualizationOT,
  title={Visualization of transient encounter complexes in protein–protein association},
  author={Chun Tang and Junji Iwahara and G. Marius Clore},
  journal={Nature},
  year={2006},
  volume={444},
  pages={383-386}
}
Kinetic data on a number of protein–protein associations have provided evidence for the initial formation of a pre-equilibrium encounter complex that subsequently relaxes to the final stereospecific complex. Site-directed mutagenesis and brownian dynamics simulations have suggested that the rate of association can be modulated by perturbations in charge distribution outside the direct interaction surfaces. Furthermore, rate enhancement through non-specific binding may occur by either a… Expand
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TLDR
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TLDR
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TLDR
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TLDR
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Transient protein encounters characterized by paramagnetic NMR
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TLDR
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