Visualization of the lipid barrier and measurement of lipid pathlength in human stratum corneum

  title={Visualization of the lipid barrier and measurement of lipid pathlength in human stratum corneum},
  author={Priva S. Talreja and Gerald B Kasting and Nancy K. Kleene and William L. Pickens and Tsuo-Feng Wang},
  journal={AAPS PharmSci},
Detailed models of solute transport through the stratum corneum (SC) require an interpretation of apparent bulk diffusion coefficients in terms of microscopic transport properties. Modern microscopy techniques provide a tool for evaluating one key property—lipid pathway tortuosity—in more detail than previously possible. Microscopic lipid pathway measurements on alkali expanded human SC stained with the lipid-soluble dyes methylene blue, Nile red, and oil red O are described. Brightfield… CONTINUE READING


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