Visualization of the binding, endocytosis, and transcytosis of low- density lipoprotein in the arterial endothelium in situ

@article{Vasile1983VisualizationOT,
  title={Visualization of the binding, endocytosis, and transcytosis of low- density lipoprotein in the arterial endothelium in situ},
  author={E Vasile and Maya Simionescu and Nicolae Simionescu},
  journal={The Journal of Cell Biology},
  year={1983},
  volume={96},
  pages={1677 - 1689}
}
We investigated the interaction and transport of low-density lipoprotein (LDL) through the arterial endothelium in rat aorta and coronary artery, by perfusing in situ native, untagged human, and rat LDL. The latter was rendered electron-opaque after it interacted with the endothelial cell and was subsequently fixed within tissue. We achieved LDL electron-opacity by an improved fixation procedure using 3,3'-diaminobenzidine, and mordanting with tannic acid. The unequivocal identification of LDL… CONTINUE READING
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