Visualization of regional tau deposits using 3H-THK5117 in Alzheimer brain tissue

  title={Visualization of regional tau deposits using 3H-THK5117 in Alzheimer brain tissue},
  author={Laetitia Lemoine and Laure Saint-Aubert and Amelia Marutle and Gunnar Antoni and Jonas Eriksson and Bernardino Ghetti and Nobuyuki Okamura and Inger Nennesmo and Per-G{\"o}ran Gillberg and A. Nordberg},
  booktitle={Acta neuropathologica communications},
INTRODUCTION  The accumulation of neurofibrillary tangles, composed of aggregated hyperphosphorylated tau protein, starts spreading early in specific regions in the course of Alzheimer's disease (AD), correlating with the progression of memory dysfunction. The non-invasive imaging of tau could therefore facilitate the early diagnosis of AD, differentiate it from other dementing disorders and allow evaluation of tau immunization therapy outcomes. In this study we characterized the in vitro… CONTINUE READING
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striatal amyloid deposits and neurofibrillary changes

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