Visualization of outflow tract development in the absence of Tbx1 using an FgF10 enhancer trap transgene.

@article{Kelly2007VisualizationOO,
  title={Visualization of outflow tract development in the absence of Tbx1 using an FgF10 enhancer trap transgene.},
  author={Robert G. Kelly and Virginia E Papaioannou},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2007},
  volume={236 3},
  pages={821-8}
}
Tbx1, the major gene underlying del22q11.2 or DiGeorge syndrome in humans, is required for normal development and septation of the cardiac outflow tract. The fibroblast growth factor 10 gene (Fgf10) and an Fgf10 enhancer trap transgene are expressed in outflow tract myocardial progenitor cells of the anterior heart field. To visualize outflow tract development in the absence of Tbx1, we have analyzed the expression profile of the Fgf10 enhancer trap transgene during outflow tract development in… CONTINUE READING
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