Visualization of nonreciprocal chromosome exchanges in irradiated human fibroblasts by fluorescence in situ hybridization.

@article{Brown1993VisualizationON,
  title={Visualization of nonreciprocal chromosome exchanges in irradiated human fibroblasts by fluorescence in situ hybridization.},
  author={Janice M. Y. Brown and Mary S Kovacs},
  journal={Radiation research},
  year={1993},
  volume={136 1},
  pages={71-6}
}
A long-standing controversy in radiation cytogenetics is the precise mechanism for the formation of chromosome exchanges. The classical breakage-and-reunion hypothesis suggested by Stadler and developed by Sax was challenged in 1959 by Revell, who proposed that radiation produced an "unstable lesion" which could interact with another such lesion to form an exchange. A difference between the predictions of these two theories is that the breakage-and-reunion hypothesis would allow the two broken… CONTINUE READING
4 Citations
0 References
Similar Papers