Visualization of neuromuscular junctions over periods of several months in living mice.

@article{Lichtman1987VisualizationON,
  title={Visualization of neuromuscular junctions over periods of several months in living mice.},
  author={Jeff William Lichtman and Lorenzo Magrassi and Dale Purves},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1987},
  volume={7 4},
  pages={1215-22}
}
Identified neuromuscular junctions were followed in the sternomastoid muscle of living mice for several months by repeated staining with the fluorescent dye 4-(4-diethylaminostyryl)-N-methylpyridinium iodide (4-Di-2-ASP; Magrassi et al., 1987). Overall terminal growth occurred at many endplates; however, the branching pattern of presynaptic arbors was largely unchanged, even after several months. The absence of significant remodeling over time was not a result of dye-staining, since sprouting… CONTINUE READING
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