Visualization of mono-allelic chromosomal aberrations 3′ and 5′ of the cyclin D1 gene in mantle cell lymphoma using DNA fiber fluorescence in situ hybridization

@article{Boer1997VisualizationOM,
  title={Visualization of mono-allelic chromosomal aberrations 3′ and 5′ of the cyclin D1 gene in mantle cell lymphoma using DNA fiber fluorescence in situ hybridization},
  author={Carla J de Boer and J Michael Vaandrager and Johan HJM van Krieken and Zandra Holmes and Philip M. Kluin and Ed Schuuring},
  journal={Oncogene},
  year={1997},
  volume={15},
  pages={1599-1603}
}
In mantle cell lymphoma (MCL), in addition to the characteristic t(11;14)(q13;q32), rearrangements on the 3′ side of the cyclin D1 gene have been described. In a series of 32 MCL we found three cases with 3′-rearrangements by Southern blot analysis with a probe representing the 3′ untranslated region of the cyclin D1 gene. All three were characterized by the absence of the 4.5 kb transcript, and instead, two cases showed overexpression of the 1.7 kb and a third case (MCLp14) an aberrant 2.5 kb… CONTINUE READING

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