Visualization of mismatch repair in bacterial cells.

@article{Smith2001VisualizationOM,
  title={Visualization of mismatch repair in bacterial cells.},
  author={Bradley T Smith and Alan D Grossman and Graham C Walker},
  journal={Molecular cell},
  year={2001},
  volume={8 6},
  pages={1197-206}
}
We determined the localizations of mismatch repair proteins in living Bacillus subtilis cells. MutS-GFP colocalized with the chromosome in all cells and formed foci in a subset of cells. MutL-GFP formed foci in a subset of cells, and its localization was MutS dependent. The introduction of mismatches by growth in 2-aminopurine caused a replication-dependent increase in the number of cells with MutS and MutL foci. Approximately half of the MutS foci colocalized with DNA polymerase foci. We… CONTINUE READING

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Isolation of an hMSH 2p 160 heterodimer that restores DNA mismatch repair to tumor cells

  • K. P. Lemon, A. D. Grossman
  • Science
  • 2001
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