Visualization of microglia in living tissues using Iba1-EGFP transgenic mice.

  title={Visualization of microglia in living tissues using Iba1-EGFP transgenic mice.},
  author={Takae Hirasawa and Keiko Ohsawa and Yoshinori Imai and Yumiko Ondo and Chihiro Akazawa and Shigeo Uchino and Shinichi Kohsaka},
  journal={Journal of neuroscience research},
  volume={81 3},
Microglia are thought to play important roles not only in repairing injured tissue but in regulating neuronal activity, and visualizing the cells is very useful as a means of further investigating the function of microglia in vivo. We previously cloned the ionized calcium-binding adaptor molecule 1 (Iba1) gene, which is expressed selectively in microglia/microphages. To generate new transgenic mice to visualize microglia with enhanced green fluorescent protein (EGFP), we here constructed a… CONTINUE READING


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