Visualization of dynamic conformational switching of the G-quadruplex in a DNA nanostructure.

@article{Sannohe2010VisualizationOD,
  title={Visualization of dynamic conformational switching of the G-quadruplex in a DNA nanostructure.},
  author={Yuta Sannohe and Masayuki Endo and Yousuke Katsuda and Kumi Hidaka and Hiroshi Sugiyama},
  journal={Journal of the American Chemical Society},
  year={2010},
  volume={132 46},
  pages={
          16311-3
        }
}
We herein report the real-time observation of G-quadruplex formation by monitoring the G-quadruplex-induced global change of two duplexes incorporated in a DNA nanoscaffold. The introduced G-rich strands formed an interstrand (3 + 1) G-quadruplex structure in the presence of K(+), and the formed four-stranded structure was disrupted by removal of K(+). These conformational changes were visualized in a nanoscaffold in real-time with fast-scanning atomic force microscopy. 
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