Visualization of doxorubicin-induced oxidative stress in isolated cardiac myocytes.

@article{Sarvazyan1996VisualizationOD,
  title={Visualization of doxorubicin-induced oxidative stress in isolated cardiac myocytes.},
  author={Narine A Sarvazyan},
  journal={The American journal of physiology},
  year={1996},
  volume={271 5 Pt 2},
  pages={
          H2079-85
        }
}
The paper presents high-resolution fluorescence images obtained using laser-scanning confocal microscopy. Isolated cells from adult rat hearts were preloaded with 2',7'-dichlorofluorescin (an oxidant-sensitive fluorescent probe) and exposed to doxo- rubicin, an important anticancer drug with prominent cardioxicity. Fluorescence images were collected from live cells simultaneously on two channels: 1) 515-530 nm emission range was used to monitor an increase in dichlorofluorescein, the oxidized… CONTINUE READING

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