Visualization of chemical modifications in the human 80S ribosome structure

@article{Natchiar2017VisualizationOC,
  title={Visualization of chemical modifications in the human 80S ribosome structure},
  author={S. K. Natchiar and A. Myasnikov and H. Kratzat and I. Hazemann and B. Klaholz},
  journal={Nature},
  year={2017},
  volume={551},
  pages={472-477}
}
Chemical modifications of human ribosomal RNA (rRNA) are introduced during biogenesis and have been implicated in the dysregulation of protein synthesis, as is found in cancer and other diseases. However, their role in this phenomenon is unknown. Here we visualize more than 130 individual rRNA modifications in the three-dimensional structure of the human ribosome, explaining their structural and functional roles. In addition to a small number of universally conserved sites, we identify many… Expand
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