Visualization of Proteus mirabilis Morphotypes in the Urinary Tract: the Elongated Swarmer Cell Is Rarely Observed in Ascending Urinary Tract Infection

@article{Jansen2003VisualizationOP,
  title={Visualization of Proteus mirabilis Morphotypes in the Urinary Tract: the Elongated Swarmer Cell Is Rarely Observed in Ascending Urinary Tract Infection},
  author={Angela M. Jansen and C. Virginia Lockatell and David E. Johnson and Harry L. T. Mobley},
  journal={Infection and Immunity},
  year={2003},
  volume={71},
  pages={3607 - 3613}
}
ABSTRACT Proteus mirabilis, a common cause of nosocomial and catheter-associated urinary tract infection, colonizes the bladder and ascends the ureters to the proximal tubules of the kidneys, leading to the development of acute pyelonephritis. P. mirabilis is capable of swarming, a form of multicellular behavior in which bacteria differentiate from the short rod typical of members of the family Enterobacteriaceae, termed the swimmer cell, into hyperflagellated elongated bacteria capable of… 
Complete Genome Sequence of Uropathogenic Proteus mirabilis , a Master of both Adherence and Motility (cid:1) †
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The complete genome sequence of P. mirabilis HI4320 is reported, a representative strain cultured in the laboratory from the urine of a nursing home patient with a long-term indwelling urinary catheter.
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TLDR
This review discusses how PM is mediated by a catheter into the urethra, bladder, and then rose to the kidney causing UTI and the main virulence factors associated with different stages of infection, including flagella, pili or adhesins, urease, hemolysin, metal intake, and immune escape, encompassing both historical perspectives and current advances.
Complete Genome Sequence of Uropathogenic Proteus mirabilis, a Master of both Adherence and Motility
TLDR
The complete genome sequence of P. mirabilis HI4320 is reported, a representative strain cultured in the laboratory from the urine of a nursing home patient with a long-term (> or =30 days) indwelling urinary catheter.
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TLDR
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TLDR
It is concluded that MR/P fimbriae are expressed by most P. mirabilis cells infecting the urinary tract, dictate the localization of bacteria in the bladder, and contribute to biofilm formation.
Proteus mirabilis Genes That Contribute to Pathogenesis of Urinary Tract Infection: Identification of 25 Signature-Tagged Mutants Attenuated at Least 100-Fold
TLDR
Isolation of disrupted genes encoding proteins with homologies to known bacterial virulence factors, especially the urease accessory protein UreF and the disulfide formation protein DsbA, showed that the CBA mouse model and mutant pools are a reliable source of attenuated mutants with mutations in virulence genes.
Proteus sp. – an opportunistic bacterial pathogen – classification, swarming growth, clinical significance and virulence factors
TLDR
Factors involved in the regulation of swarming phenomenon are presented, the role of particular pathogenic features of Proteus spp.
Zinc Uptake Contributes to Motility and Provides a Competitive Advantage to Proteus mirabilis during Experimental Urinary Tract Infection
TLDR
A role for ZnuC in zinc transport is demonstrated and it is hypothesize that there is limited zinc present in the urinary tract and P. mirabilis must scavenge this ion to colonize and persist in the host.
Proteus mirabilis isolates of different origins do not show correlation with virulence attributes and can colonize the urinary tract of mice.
TLDR
The results obtained in this study suggest that the source of P. mirabilis strains cannot be correlated with pathogenic attributes, and that the distribution of virulence factors between isolates of different origins may correspond to the opportunistic nature of the organism.
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