Visualization of Myc/Max/Mad family dimers and the competition for dimerization in living cells.

@article{Grinberg2004VisualizationOM,
  title={Visualization of Myc/Max/Mad family dimers and the competition for dimerization in living cells.},
  author={Asya V Grinberg and C H Hu and Tom Klaus Kerppola},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 10},
  pages={4294-308}
}
Myc and Mad family proteins play opposing roles in the control of cell growth and proliferation. We have visualized the subcellular locations of complexes formed by Myc/Max/Mad family proteins using bimolecular fluorescence complementation (BiFC) analysis. Max was recruited to different subnuclear locations by interactions with Myc versus Mad family members. Complexes formed by Max with Mxi1, Mad3, or Mad4 were enriched in nuclear foci, whereas complexes formed with Myc were more uniformly… CONTINUE READING

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